Dr. Henry Windle

• B Mee, D Kelleher, J Frias, R Malone, KF Tipton, GT Henehan, HJ Windle, Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori. An aldehyde dismutating enzyme, FEBS J, 272, (5), 2005, p1255 - 1264Journal Article, 2005, DOI , TARA - Full Text
• Nolan, D., Jackson, D. G., Windle, H. J., Pays, A., Geuskens, M., Michel, A., Voorheis, H. P. and Pays, E., Characterization of a novel, stage-specific, invariant surface protein in Trypanosoma brucei containing an internal, serine-rich, repetitive motif, Journal of Biological Chemistry, 272, (46), 1997, p29212 - 29221Journal Article, 1997, DOI
• Redpath MB, Windle H, Nolan D, Pays E, Voorheis HP, Carrington M, ESAG11, a new VSG expression site-associated gene from Trypanosoma brucei., Molecular and biochemical parasitology, 111, (1), 2000, p223-228Journal Article, 2000, DOI

Infectious pathogens: Helicobacter pylori, Fusobacterium nucleatum, Campylobacter showae, Clostridium difficile

• Title

  Development of Clostridium difficile vaccine
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  2002
  Date To

  2005
• Title

  Evaluation of the carcinogenic potential of Fusobacterium nucleatum
  Summary

  Identification of the constituent bacterial species of the intestinal microbiota under normal and disease conditions has led to the identification of associations between dysbiosis and several chronic disease states. In this regard, an association between the bacterium Fusobacterium nucleatum and intestinal cancer has been identified. Originally this organism was identified as an oral pathogen responsible in part for periodontitis but now is found to be significantly associated with several extraoral dieases, including colon cancer. Interestingly, this pathogen is also enriched at sites of adenoma formation, the precursors of carcinoma, suggesting that it may be a primary initiator of carcinogenesis. Although causality has not yet been established there is compelling evidence indicating a primary role for this pathogen in disease progression. This project aims to investigate the pathogenic/carcinogenic potential of F. nucleatum using in vitro models by evaluating its ability to induce a pro-inflammatory environment and modulate/subvert cellular signalling pathways.
  Funding Agency

  Dept of Education, Government of Saudi Arabia
  Date From

  2013
  Date To

  2016
• Title

  Evaluation and Control of Neglected Mucosal Enteric Infections in Childhood
  Summary

  Microbial enteric pathogens are a major cause of childhood morbidity world-wide, contributing to impaired growth and cognitive function. In developing countries the diversity of childhood enteric infections makes diagnosis and disease surveillance difficult. To date there has been limited data on the impact of the major childhood infection Helicobacter pylori on global health issues in children in underdeveloped regions of the world. Initial infection with H. pylori is associated with a period of hypochlorhydria (reduced acid secretion), which we hypothesise is critical for the aquistion of other enteric infections, diarrhoeal disease and impaired childhood growth. In addition, we hypothesise that gastric H. pylori infection is a contributory factor to iron deficiency anaemia in childhood. The objective of the CONTENT project is to improve knowledge and apply new technologies to improve the control of neglected enteric pathogens in socio-economically disadvantaged childhood populations of Latin America
  Funding Agency

  European Union
  Date From

  2006
  Date To

  2010
• Title

  Development of a Helicobacter pylori vaccine
  Summary
  Funding Agency

  Enterprise Ireland
  Date From

  2009
  Date To

  2010